At least two grenades exploded in a bus parking lot in Bujumbura's city centre on Monday at around 7pm, a police source and eyewitnesses said.
The third blast targeted a market, killing at least two people and injuring several others, the Iwacu newspaper reported.
The blasts in Bujumbura followed a deadly grenade explosion in a bar in the capital Gitega on Sunday and a series of mortars launched on Burundi's international airport Saturday night.